Q: Why hemodialysis (HD) is more effective than fomepizole in methanol toxicity?


Answer: Early HD may be more effective in methanol toxicity since endogenous clearance of methanol in those treated with fomepizole is slow.



References: 

1.  Gonda A, Gault H, Churchill D, Hollomby D. Hemodialysis for methanol intoxication. Am J Med 1978; 64:749. 

2. Brent J, McMartin K, Phillips S, et al. Fomepizole for the treatment of methanol poisoning. N Engl J Med 2001; 344:424.