Q: Harvey-Bradshaw Index (HBI) is a grading system for the severity of which disease? 

A) Crohn Disease
B) Ulcerative Colitis
C) Acute appendicitis
D) Acute Peritonitis
E) Diverticulitis

Answer: A

Crohn's Disease Activity Index (CDAI) is a commonly used grading system to measure the severity of Crohn disease. Harvey-Bradshaw Index (HBI) is created as a simplified version of CDAI.

0-149 points: Asymptomatic remission
150-220 points: Mildly to moderately active Crohn's disease
221-450 points: Moderately to severely active Crohn's disease
451-1100 points: Severely active to fulminant disease

A Harvey-Bradshaw Index of less than 5 correlates with clinical remission.

References:

1. Harvey RF, Bradshaw JM. A simple index of Crohn's disease activity. Lancet. 1980 Mar 8;1(8167):514.

2. Best WR. Predicting the Crohn's disease activity index from the Harvey-Bradshaw Index. Inflamm Bowel Dis. 2006 Apr;12(4):304-10. 

3. Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976 Mar;70(3):439-44.