Q: What does "Time Zero" means in Upper GI bleed management?


Answer:   According to guidelines, "Time Zero" technically means the time of admission to a medical care facility. All other terms like 'clinically significant bleeding', 'acute bleeding episode', 'treatment failure', 'fresh hematemesis', 'early or late  rebleeding' etc. get defined from "time Zero" for a better perspective.


Reference: 

1. de Franchis R, Baveno V Faculty. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2010; 53:762.