Q: Cisatracurium is the most commonly used neuromuscular blockade in ICU. Which one common pitfall should be kept in mind while using this drug? 


Answer: Patients with profound sepsis may require higher dose as they may not only have a delayed response but also reduced response to described standard dosing regimens in textbooks.



Reference:

Liu X, Kruger PS, Weiss M, Roberts MS. The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis. Br J Clin Pharmacol 2012; 73:741.