Q:  Indomethacin is one of the NSAID which is used in nephrogenic DI (Diabetes Insipidus). What is the mehansim of action?


Answer: NSAIDs are used as an adjuvant treatment in DI. NSAIDs may act by inhibiting prostaglandin synthesis in Diabetes Insipidus. Inhibition of prostaglandin synthesis reduces the delivery of solute to distal tubules, reducing urine volume and increasing urine osmolality.