Daptomycin and Eosinophilic pneumonia

Daptomycin may cause eosinophilic pneumonia, somewhere between 2 to 4 weeks after initiation of daptomycin therapy. in 2010 seven confirmed cases were reported and 36 were suspicious of it. Symptoms resolved when daptomycin was discontinued but recurred in two patients when the drug was restarted.

Eosinophilic pneumonia should be suspected in patients receiving daptomycin who develop new or worsening fever, cough or dyspnea. Peripheral eosinophilia may or may not be present, but BAL eosinophil counts are usually elevated. The primary treatment is discontinuation of daptomycin, along with respiratory support and, +/- , steroids.